Technology Insights
Vaccines
Live Vaccines
Cold Chain
Biologics
Injections
Autoinjectors
Dry Powder Ambient Storage
Inhaled Route?
Single Dose Inhalers
Recombining Syringes
Liquid
Sterile Products
Vial and Syringe
Auto – Injectors
Vaccines are generally biological products, so not synthetic organic chemicals. Thus they are sensitive to heat degradation and often need cold-chain storage from manufacture to point of delivery. Sterile production methods for cell growth, harvest, inoculation with attenuated virus (as an example) are expensive and difficult to maintain. Sterile filling lines for biologics for injection without air inclusion in the Primary Container is also needed.
The TAP Blosystems fully robotic cellmate® made vaccine was Varivax (Varicella inoculation) for Merch in 1991.
In 2022 the use of disposable T flasks and disposable roller bottles vaccine manufacture is not ideal in a low-carbon future.
Marking vaccines is difficult. Stainless steel vessels, controlled temperatures, plumbing and liquids everywhere.
Covid Vaccines all needed cold chain, one down to -70°C. All covid vaccines were delivered by HCP’s at treatment centres using syringes subQ.
Small molecules, combination treatments, triples, 4 drug systems, soft mist nebuliser, low-gap propellants